Isotopically Labeled Compounds
Medchemexpress LLC Florfenicol-d3 | 2213400-85-0 | 1MG
Florfenicol-d3 is a deuterium-labeled version of Florfenicol, a veterinary antibiotic used for bovine respiratory disease and to control enteric septicemia in catfish. It has been shown to induce early embryonic death in eggs. Florfenicol-d3 can be used as a tracer and as an internal standard for quantitative analysis. Deuteration, the incorporation of stable heavy isotopes, is explored for its potential to influence the pharmacokinetic and metabolic profiles of drugs.
![Medchemexpress LLC 4H-Pyrido[1,2-a]pyrimidin-4-one, 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl-... | 1020719-76-9 | 99.4% | 414.51 | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg)
Medchemexpress LLC 4H-Pyrido[1,2-a]pyrimidin-4-one, 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl-... | 1020719-76-9 | 99.4% | 414.51 | 50 MG
Risperidone-d4 is the deuterium-labeled version of Risperidone. Risperidone functions as a serotonin 5-HT2 receptor blocker, a P-Glycoprotein inhibitor, and a potent dopamine D2 receptor antagonist. It exhibits Ki values of 4.8 nM for the 5-HT2A receptor and 5.9 nM for the dopamine D2 receptor. This product is intended for research use only and is not sold to patients.
- Can be utilized as a tracer.
- Serves as an internal standard for quantitative analysis using techniques such as NMR, GC-MS, or LC-MS.
- Incorporates stable heavy isotopes of hydrogen, carbon, and other elements into drug molecules, primarily for quantitation as tracers during drug development.
- Deuteration has the potential to influence the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Pyridoxine-d5 (Pyridoxol-d5) | 688302-31-0 | 95.0% | 1 MG
Pyridoxine-d5 (Pyridoxol-d5) is a deuterium labeled Pyridoxine. Pyridoxine is a pyridine derivative that exerts antioxidant effects in a cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Cycloguanil-d6 (chlorguanide triazine-d6) | 516-21-2 | 98.0% | 1 MG
Cycloguanil-d6 is a deuterium-labeled version of Cycloguanil, a dihydrofolate reductase (DHFR) inhibitor. It disrupts the folate metabolic pathway, affecting nucleotide synthesis and DNA replication. This compound inhibits DHFR in Plasmodium, useful in malaria research, and also in human cancer cells, demonstrating anticancer properties. Stable heavy isotopes are incorporated for use as tracers in drug development.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Inhibits dihydrofolate reductase (DHFR).
- Disrupts the folate metabolic pathway.
- Affects nucleotide synthesis and DNA replication.
- Useful in malaria research.
- Demonstrates anticancer properties.
Medchemexpress LLC Sodium propionate-d5 | 202529-18-8 | >99.91% | 5 MG
Sodium propionate-d5 | 202529-18-8 | >99.91% | 5 MG
Medchemexpress LLC Buspirone-d8 hydrochloride | 1216761-39-5 | 1 MG
Buspirone-d8 (hydrochloride) is the deuterium labeled Buspirone hydrochloride. Buspirone hydrochloride is an anxiolytic psychotropic agent, used to treat generalized anxiety disorder (GAD).
- This compound can be used as a tracer.
- This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Veratrole-d4 (1,2-Dimethoxybenzene-d4) | 126840-15-1 | 50 MG
Veratrole-d4 (1,2-Dimethoxybenzene-d4) is the deuterium-labeled form of Veratrole. Veratrole (1,2-Dimethoxybenzene) is a significant compound found in plants, where it plays a role in attracting pollinators, influencing plant reproduction, species differentiation, and interactions with pollinators. This compound also undergoes demethylation by cytochrome P-450 in Streptomyces setonii. Veratrole-d4 is intended for research use only.
- Can be utilized as a tracer in research applications.
- Suitable for use as an internal standard for quantitative analysis methods such as NMR, GC-MS, or LC-MS.
- Incorporates stable heavy isotopes, which can potentially affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Terconazole-d4 | 1398065-50-3 | 1 MG
Terconazole-d4 is a deuterium-labeled form of Terconazole, a broad-spectrum antifungal medication primarily used for treating vaginal yeast infections. Deuteration may impact the pharmacokinetic and metabolic profiles of the drug.
- Deuterium-labeled compound
- Broad-spectrum antifungal
- Targets fungal pathogens
- Used for vaginal yeast infection treatment
- May affect pharmacokinetic and metabolic profiles
Medchemexpress LLC Fingolimod-d4 | 1346747-38-3 | 99.1% | 311.50 | 1 ML
Fingolimod-d4 is the deuterium labeled Fingolimod. Fingolimod (FTY720 free base) is a brain-penetrant sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, an immunosuppressant.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes have been incorporated for quantitation during drug development.
- Deuteration has potential to affect pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC N-Ethylmaleimide-d5 | 360768-37-2 | 99.9% | 5 MG
N-Ethylmaleimide-d5 is the deuterium labeled N-Ethylmaleimide. N-Ethylmaleimide (NEM) is a reagent that alkylates free sulfhydryl groups, a cysteine protease inhibitor, and specifically inhibits phosphate transport in mitochondria. It is also a deubiquitinating enzyme inhibitor.
- Deuterium labeled N-Ethylmaleimide.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC L-Carnitine-d9 chloride | 2687961-04-0 | 99.0% | 1 MG
L-Carnitine-d9 chloride is the deuterium-labeled L-Carnitine chloride. L-Carnitine chloride is a highly polar, small zwitterion that acts as an essential co-factor for the mitochondrial β-oxidation pathway. Its function is to transport long-chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. Additionally, L-Carnitine chloride is an antioxidant and can help ameliorate metabolic imbalances in various inborn errors of metabolism.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC (Rac)-Atropine-d3 | 1276197-36-4 | 99.1% | 5 MG
(Rac)-Atropine-d3 is the deuterium labeled (Rac)-Atropine, designed for research use only. It serves as a tracer and internal standard for quantitative analysis using techniques such as NMR, GC-MS, or LC-MS. Deuteration, the substitution of deuterium for hydrogen, is recognized for its potential to influence the pharmacokinetic and metabolic profiles of drugs.
- Used as a tracer in analytical studies
- Functions as an internal standard for quantitative analysis
- Suitable for NMR, GC-MS, and LC-MS applications
- Deuteration may affect pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC Uric acid-15N2 | 62948-75-8 | 99.9% | 5 MG
Uric acid-15N2 is the 15N labeled Uric acid. Uric acid is an important antioxidant and scavenger of oxygen radicals, contributing to the stability of blood pressure and antioxidant stress. It removes reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, which helps inhibit lipid peroxidation.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis.
- Stable heavy isotopes have been incorporated into molecules for quantitation during the development process.
- Deuteration can potentially affect the pharmacokinetic and metabolic profiles of substances.
Medchemexpress LLC Triclocarban-d4 | 1219799-29-7 | 98.0% | 5 MG
Triclocarban-d4 is the deuterium labeled version of Triclocarban. Triclocarban (3,4,4′-Trichlorocarbanilide) is a broad-spectrum antibacterial compound commonly used in various products such as soaps, skin creams, toothpastes, and deodorants. It is also considered a potential endocrine-disrupting chemical that can modulate androgen and estrogen activities, as well as other hormone-mediated biological processes.
- Used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.